Mechanism of auto-inhibition and activation of Mec1ATR checkpoint kinase
نویسندگان
چکیده
منابع مشابه
Probing the Mec1ATR Checkpoint Activation Mechanism with Small Peptides.
Yeast Mec1, the ortholog of human ATR, is the apical protein kinase that initiates the cell cycle checkpoint in response to DNA damage and replication stress. The basal activity of Mec1 kinase is activated by cell cycle phase-specific activators. Three distinct activators stimulate Mec1 kinase using an intrinsically disordered domain of the protein. These are the Ddc1 subunit of the 9-1-1 check...
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We use a novel normal mode analysis of an elastic network model drawn from configurations generated during microsecond all-atom molecular dynamics simulations to analyze the mechanism of auto-inhibition of AMP-activated protein kinase (AMPK). A recent X-ray and mutagenesis experiment (Chen, et al Nature 2009, 459, 1146) of the AMPK homolog S. Pombe sucrose non-fermenting 1 (SNF1) has proposed a...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2020
ISSN: 1545-9993,1545-9985
DOI: 10.1038/s41594-020-00522-0